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Copper Peptides
In the snail's body tissues, glycosaminoglycans (GAGs) are primarily located inside granules and in the shell, and are secreted onto the surface as a mucous material. Snail glycosaminoglycan tightly binds divalent copper cations (Cu 2+) and form copper peptides , with reportedly have skin regeneration properties. The concentration of copper in the snail mucins is notable, but copper peptides have been shown to be active in nanomolar amounts.
Copper-induced vascular endothelial growth factor expression and wound healing. Sen CK, Khanna S, Venojarvi M, Trikha P, Ellison EC, Hunt TK, Roy S. 2002 May;282(5):H1821-7. http://ajpheart.physiology.org/cgi/content/full/282/5/H1821
Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart & Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
Angiogenesis - the growth of new blood vessels - plays a central role in wound healing. Among many known growth factors, vascular endothelial growth factor (VEGF) is believed to be the most prevalent, efficacious, and long-term signal that is known to stimulate angiogenesis in wounds. Whereas a direct role of copper to facilitate angiogenesis has been evident two decades ago, the specific targets of copper action remained unclear. This report presents first evidence showing that inducible VEGF expression is sensitive to copper and that the angiogenic potential of copper may be harnessed to accelerate dermal wound contraction and closure. At physiologically relevant concentrations, copper sulfate induced VEGF expression in primary as well as transformed human keratinocytes. Copper shared some of the pathways utilized by hypoxia to regulate VEGF expression. Topical copper sulfate accelerated closure of excisional murine dermal wound allowed to heal by secondary intention. Copper-sensitive pathways regulate key mediators of wound healing such as angiogenesis and extracellular matrix remodeling. Copper-based therapeutics represents a feasible approach to promote dermal wound healing.
Certain types of copper peptide complexes possess both tissue protection and repair properties. Cu has protective and regenerative actions on several organ systems including skin, hair follicles, bone, gastric mucosa and intestinal linings. These types of copper complexes are increasingly used in cosmetic skin and hair care products and after dermatological skin renewal procedures, such as chemical peels, laser resurfacing and dermabrasion, to improve post-treatment skin recovery .
Aging reversal of skin
The greatest interest in copper peptides is in the area of reversing the effects of human ageing and ultraviolet damage on human skin. During ageing, skin becomes thinner and tends to accumulate various skin lesions and imperfections. The dermis and epidermis thin and the subcutaneous fat cells diminish in number.
A number of studies have found that the application of copper peptide creams to the human skin is more effective in promoting collagen development than retinoic acid or vitamin C. It also increase s the thickness of the epidermis and dermis, increases skin elasticity, reduces wrinkles and removes skin imperfections such as blotchiness and sun damage marks.
For the treatment of newly formed stretch marks, to strengthen fragile skin, tighten and firm breasts and other areas, reduce cellulite and prevent stretch marks during pregnancy.
Made in the USA. One Month's supply 180 grams = 6 oz
Regular Price for 180 Grams in One Airless Pump Bottle: $119.00
Ultra Exfoliate Your Skin with BIOSKINEXFOL
A home microdermabrasion cream with the same high quality micro-crystals professionals use to breakdown hard, rough and old scar tissues, and allow for a deeper penetration of our exclusive natural skin moisturizing and skin regeneration complex compound contained in the microdermabrasion cream. For old and rough scars and stretch marks and to get rid of mild actinic keratosis scales before they turn into pre-cancerous formations. Not for keloids.
Made in the USA. Two to Three Month's supply 120 grams = 4.23 oz
120 Gram Bottle: $79
BIOCUTIS skin treatment products
BIOSKINEXFOL™
A home micro-dermabrasion cream with high quality micro-crystals, the same that professionals use to breakdown and polish away hard, rough and old scar tissues. It allows for a deeper penetration of our all natural skin moisturizing and regeneration complex that is combined with the crystals in the microdermabrasion cream. 120 gram (4 oz) jar = $79
BIO STRETCH MARK CREAM™
Helps to prevent pregnancy stretch marks, strengthen fragile skin, firm sagging breasts and body areas and reduce cellulite. It also works for newly formed stretch marks and scars, while BIOSKINEXFOL is recommended for old, rough and raised marks. This product is similar to BIOSKINCARE, although in a more economic container, with 6 oz. For use preferably on the body, not on the face, for it contains a higher concentration of our natural biological complex which results in an invisible film that retains in moisture by occluding the area where it is applied and could feel a little tacky on the face depending on how oily is your facial skin. 6 oz (180g) tottle = $119.00
BIOSKINCLEAR™
Oil free moisturizing gel for acne, rosacea and facial scars, for people with very oily skin complexion. The product is based on the natural glycoconjugates compound produced by a little creature to function as its powerful immune modulator and skin regeneration trigger. Removes dead cells, unclogs sebum canals and dissolves scar tissues by enzymatic hydrolysis, without peeling. Promotes the secretion of antimicrobials on the skin surface that keep micro-organisms at bay and controls acne bacteria. Boosts the production of glycosaminoglycans, the molecules that hold in water in the dermis, thus truly moisturizing the skin from within. Communicates to your immune system that you are being taken care of and can moderate an otherwise extreme inflammatory reaction that may end up destroying healthy skin cells together with bacteria and sebum that has turned into a foreign matter. 50 gram (1.76 oz) airless pump bottle $49 and 20% off for two or more.
BIOSKINCARE™
A deeply moisturizing natural skin care cream that triggers the regeneration of damaged cells and replenishes the lipid barrier of the skin while preventing and removing scars from accidental injuries and post surgery; stretch marks; hypertrophic and keloid scars; keratois pilaris, actinic keratosis, dermatitis, psoriasis scales and all types of skin blemishes. 50 gram (1.76 oz) jar = $59.98 and for two or more 20% discount.
BIO SKIN REJUVENATION™
Same cream base and enzymes as in BIOSKINCARE to "digest" or dissolve blemishes, speed skin turnover, moisturize and tighten skin, and two added ingredients: a natural pigment reducer and a human growth factor peptide, derived from the melanocyte-stimulating-hormone that blocks melanin synthesis, and inhibits the formation of unwanted pigmentation, allowing control over skin tone and brown spots. Leaves skin bright and refreshed! 50 gram (1.76 oz) jar = $69.98.
